Home » (30 pts) An important physical characteristic in pharmacology

(30 pts) An important physical characteristic in pharmacology

2. (30 pts) An important physical characteristic in pharmacology is the fat-blood partitioncoefficient. This is the equilibrium concentration of a drug in fatty tissues (a relatively oilyphase) divided by the concentration of drug in blood (an aqueous phase). If the fat-bloodpartition coefficient is high, the majority of a drug will be transferred to fatty tissue duringadministration. The fat-blood partition coefficient of the anesthetic n-butyl 4-aminobenzoate isreported to be 575.4 at pH = 7.4.Calculate the free energy per mole to transport n-butyl 4-aminobenzoate from fatty tissue to blood. At pH = 7.4, n-butyl 4-aminobenzoate is notprotonated, so you may assume that equations for uncharged species can be used.3. (30 pts) Modified from Chapter 6, Problem 16, parts (a), (b), and (d).a. Assuming that glucose and water form an ideal solution, what is the partial pressure ofwater at 20oC of a solution of 1.00 g of glucose (mol wt 180 g/mol) in 100 g of water?The vapor pressure of pure water is 2338 Pa at 20oC.b. What is the osmotic pressure, in Pa, of the solution in part (a) versus pure water?d. What would be the osmotic pressure, in Pa, of a solution containing both 1.00 g ofglucose and 1.00 g of sucrose (mol wt 342) in 100 g of water at 20oC?

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